Ed W. Childs, MD, FACS

Ed W. Childs, MD, FACS 

Chair & Professor for Trauma and Critical Care

Surgery

Phone: 404-616-1426
E-mail: echilds@msm.edu

Education

POSTGRADUATE:
University of Kansas Medical Center, Kansas City, KS
Residency: General Surgery

University of Kansas Medical Center, Kansas City, KS
Fellowship: Trauma/Critical Care

GRADUATE:
Texas A & M Health Science Center, College Station, TX
Degree: MD

UNDERGRADUATE:
University of Texas, Dallas, TX
Degree: BA, Molecular and Cellular Biology

Research Interests

  • Microvascular Injury Following Hemorrhagic Shock
  • Apoptotic Signaling Following Hemorrhagic Shock
  • Apoptotic Signaling Following Burn
  • Vascular Hyperpermeability
  • Tonsillar Abscess   
  • Takayasu’s Arteritis  
  • Gallbladder Carcinoma
  • Alpha Lipoic Acid Attenuates HS-induced Leukocyte Adherence
  • Challenging Trauma Cases
  • Contemporary Management of ARDS 
  • Blunt Chest Trauma
  • Pelvic Fractures
  • Trauma and Pregnancy
  • Troponin I in the Evaluation of Blunt Myocardial Injury
  • Compartment Syndrome
Shock
  • Effect of Monoclonal Antibody LFA-1 on Leukocyte Adherence
  • Following Hemorrhagic Shock in Rats
  • WEB 2086 on Leukocyte Adherence Effects Following Hemorrhagic
Shock in Rat
  • Hemicorporectomy and Associated Complications
  • Leukocyte Dynamics     
  • LA, Role of ROS Generation Following
  • Hemorrhagic Shock    
  • Hypothermia Attenuates
  • Microvascular Permeability Following Hemorrhagic Shock
  • Evidence of Transcellular Permeability Following Hemorrhagic Shock
  • Fluid Management and Resuscitation of the Trauma Patient
  • Management and Resuscitation of the Trauma Patient   
  • SHOCK, Halifax, Nova Scotia, Canada, Morphine’s effect on Venular Permeability and Leukocyte Adherence    
  • Experimental Biology 2005, San Diego, CA, Angiopoietin-1 Inhibits BAK (BH3)-Induced Endothelial Cell Hyperpermeability
  • Cyclosporin A inhibits HS-induced Hyperpermeability
  • Inhibits Smac Release and Mitochondrial Transition Pores 
  • Curcumin Attenuates Endothelial Cell Hyperpermeability by Inhibiting ROS Generation 
  • Cyclosporin-A Attenuates Vascular Permeability in Hemorrhagic Shock through Anti-apoptotic Mechanisms
  • Angiopoietin-1 Attenuates Microvascular Permeability and Decreases Cytoplasmic Smac Levels Following Hemorrhagic Shock
  • Attenuates Hemorrhagic Shock-Induced Vascular Permeability and Caspase-3 Activity
  • Curcumin Attenuates Endothelial Cell Hyperpermeability by Inhibiting ROS Generation     Caspase-3 key Mediator of Vascular Hyperpermeability Following Hemorrhagic Shock
  • Alpha Lipoic Acid Inhibits Mitochondrial ROS Formation and Vascular Hyperpermability Following Hemorrhagic Shock
  • 17B-Estradiol Inhibits Apoptotic Signaling and Microvascular Endothelial Cell Hyperpermeability, Sex and Gender in Cardiovascular Renal Physiology and Pathophysiology
  • Pathophysiology of Shock & Trauma    
  • Mitochondrial Respiratory Chain Complex-III is Involved in BAK (BH3) Mediated ROS Generation and Microvascular Endothelial Cell Hyperpermeability  
  • Curcumin Prevents Vascular Hyperpermeability Following Hemorrhagic Shock
  • Alpha Lipoic Acid Prevents Microvascular Hyperpermeability By Acting Upstream of Caspase-3 Activation  
  • (-) Deprenyl Attenuates Microvascular Endothelial Cell Hyperpermeability by Inhibiting Intrinsic Apoptotic Signaling 
  • 17B-Estradiol Iinhibits Apoptotic Signaling and Microvascular Endothelial Cell Hyperpermeability
  • Alpha Lipoic Acid Inhibits Mitochondrial ROS Formation and Vascular Hyperpermeability Following Hemorrhagic Shock 
  • Caspase-3 is A Key Mediator of Vascular Hyperpermeability Following Hemorrhagic Shock
  • 17B-Estradiol Inhibits Apoptotic Signaling and Microvascular Endothelial Cell Hyperpermeability
  • (-) Deprenyl Attenuates Vascular Hyperpermeability Following Hemorrhagic Shock
  • (-) Deprenyl attenuates Burn Induced-Hyperpermeability and Intrinsic Apoptotic Signaling in Microvascular Endothelial Cells
  • Estradiol Inhibits Vascular Hyperpermeability Following Hemorrhagic Shock
  • Estrogen Receptors are involved in the 17-beta Estradiol Mediated Protection Against Microvascular Endothelial Cell Hyperpermeability
  • Evidence for Endothelial Cell Adherens Junction Damage in Hemorrhagic Shock Induced Hyperpermeability
  • Burn Injury Activates Intrinsic Apoptotic Signaling and Induces Vascular Hyperpermeability
  • 17B-Estradiol Mediated Protection Against Vascular Hyperpermeability Following Hemorrhagic Shock: Regulation of Estrogen Receptors
  • VE Cadherin Dynamics During Microvascular Endothelial Cell Hyperpermeability
  • Cyclosporin Inhibits Microvascular Endothelial Cell Hyperpermeability Iindependent of Calcineurin Iinhibition
  • Apoptotic Signaling Regulates Vascular Hyperpermeability Following Hemorrhagic Shock 
  • Hemorrhagic Shock Serum Induces ROS Formation, Activation of Apoptotic Signaling and Endothelial Cell Monolayer Hyperpermeability 
  • Vascular Hyperpermeability, Matrix Metalloproteinase 9 Induces Hyperpermeability Following Traumatic Burn Injury
  • Regulation of Hemorrhagic Shock-Induced Vascular Hyperpermeability by 17β-Estradiol
  • Hemorrhagic Shock and Hyperpermeability
  • Hemorrhagic Shock-Induced Hyperpermeability  
  • β-Catenin Cytoplasmic Stabilization Attenuates Microvascular Endothelial Cell Hyperpermeability.
  • Component Therapy in Trauma Resuscitation
  • Activation of a β-catenin Mediated Wnt Signaling Pathway in Microvascular Endothelial Cells     
  • (-) Deprenyl inhibits Microvascular Endothelial cell Hyperpermeabilty Independent of MAO Inhibition
  • GSK-3β Inhibition attenuates vascular hyperpermeabiltiy following hemorrhagic shock Matrix metalloproteinase-9 induces vascular hyperpermeability following traumatic burn
  • Role of Beta Catenin in Regulating Microvasclar Endothelial Cell Permeability    
  • β-Catenin Cleavage and Microvascular Endothelial Cell Hyperpermeability Induced by Staurosporine 
  • Staurosporine induces brain microvascular endothelial cell hyperpermeability through intrinsic apoptotic signaling pathway 
  • TNF-α Induced Microvascular Endothelial Cell Hyperpermeability
  • Role of Mitochondrial Fission in Regulating Microvascular Endothelial Cell Hyperpermeability
  • Differential Involvement of IKKα and IKKβ in Regulating Microvascular Endothelial Cell Barrier Integrity
  • MO, Role of B-Catenin in Regulating Microvascular Endothelial Cell Hyperpermeability 

Board Certification

  • American Board of Surgery (General Surgery)
  • American Board of Surgery (Trauma and Critical Care)

Publications

  • Jas GS, Childs EW, Middaugh CR, Kuczera K. Dissecting Multiple Pathways in the Relaxation Dynamics of Helix <==> Coil Transitions with Optimum Dimensionality Reduction. Biomolecules. Sep 12;11(9):1351, 2021.
  • Tharakan B, Hunter FA, Childs E. W. Protective Effects of FK 506 Against Hemorrhagic Shock-Induced Microvascular Hyperpermeability [published online ahead of print, 2021 Aug 25]. Clin Exp Pharmacol Physiol. 2021;10.1111/1440-1681.13578. doi:10.1111/1440-1681.13578
  • Jas GS, Childs EW, Middaugh CR, Kuczera K. Probing the Internal Dynamics and Shape of Simple Peptides in Urea, Guanidinium Hydrochloride, and Proline Solutions with Time-Resolved Fluorescence Anisotropy and Atomistic Cosolvent Simulations. J Phys Chem B. Oct 7;125(39):10972-10984, 2021.
  • Turner, J., Higgins, R., Childs, E. W., (2021). Microaggression and Implicit Bias. The American surgeon, 31348211023418. Advance online publication.
  • Jas GS, Childs EW, Middaugh CR, Kuczera K. Observing reorientation dynamics with Time-Resolved fluorescence and molecular dynamics in varying periodic boundary conditions. J Biomol Struct Dyn. Jul 24:1-15, 2021
  • Hoard R., Butler C., Sola R., Koganti D., Fobare A., Gelbard R., Nguyen G., Rajani R.., Henry B., Udobi K., Childs E.W., Danner O. Successful Treatment of Dual Juxtahepatic Inferior Vena Cava Injuries Using Formal Atriocaval Shunt: A case Report and Review of the Literature. Science Suppository May 13.2020.
  • Brent L. Lee, Krzysztof Kuczera, Kyung-Hoon Lee, Childs, E.W. & Gouri S. Jas (2020): Unassisted N-acetyl-phenylalanine-amide transport across membrane with varying lipid size and composition: kinetic measurements and atomistic molecular dynamics simulation, Journal of Biomolecular Structure and Dynamics, DOI: 10.1080/07391102.2020.
  • Chounoune, R., Kpodzo, D., Udobi, K., Sola, R., Nguyen, J., Matthews, L. R., Childs, E.W., Danner, O. Sepsis Due to Deep Posterior Neck Abscesses Secondary to Prevotella Bivia: Beware of Emerging Opportunistic Pathogens. Herold Scholarly Open Access Journal of Clinical Studies and Medical Case Reports August 12.2019. 

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Honors and Awards

  • 2022 Navarro College Alumni Honor
  • 2019 ÁñÁ«ÊÓƵ Outstanding Contribution
  • 2019 National Medical Association Region III Leadership Award
  • 2018 NAACP Texas Chapter Leadership Award